The latest breakthrough in stem cell research turns skin cells into stem cells just as useful as embryonic stem cells, without the ethical issues. Adult stem cells and induced stem cells, while still able to become many other types of cells, still had some limitations. Researchers are saying, however, that stem cells using this new method, are just like embryonic.

We are getting to the point that using actual embryos is going to be completely unnecessary. It’ll be almost medieval to suggest using them, when skin (which is the largest organ in your body; did you know that?) are able to produce what’s required. I wonder how much the advance of methods to create embryonic-like stem cells was pushed forward by George W. Bush’s restriction of embryonic stem cell lines that could be used. Bush, then, was not anti-science, but pro-ethical-science.

US researchers have reported a breakthrough in stem cell research, describing how they have turned human skin cells into embryonic stem cells for the first time.

The method described Wednesday by Oregon Health and Science University scientists in the journal Cell, would not likely be able to create human clones, said Shoukhrat Mitalipov, senior scientist at the Oregon National Primate Research Center.

But it is an important step in research because it does not require the use of embryos in creating the type of stem cell capable of transforming into any other type of cell in the body.

The technique involves transplanting an individual’s DNA into an egg cell that has been stripped of genetic material, a variation of a method called somatic cell nuclear transfer.

"A thorough examination of the stem cells derived through this technique demonstrated their ability to convert just like normal embryonic stem cells, into several different cell types, including nerve cells, liver cells and heart cells," said Mitalipov.

If it is, it may not be in the way  you’ve been told.

Don’t look now, but maybe a scientific consensus exists concerning global warming after all. Only 36 percent of geoscientists and engineers believe that humans are creating a global warming crisis, according to a survey reported in the peer-reviewed Organization Studies. By contrast, a strong majority of the 1,077 respondents believe that nature is the primary cause of recent global warming and/or that future global warming will not be a very serious problem.

Is this some sort of sea change? Again, not necessarily.

Another interesting aspect of this new survey is that it reports on the beliefs of scientists themselves rather than bureaucrats who often publish alarmist statements without polling their member scientists. We now have meteorologists, geoscientists and engineers all reporting that they are skeptics of an asserted global warming crisis, yet the bureaucrats of these organizations frequently suck up to the media and suck up to government grant providers by trying to tell us the opposite of what their scientist members actually believe.

An inconvenient truth, to be sure.

Be wary of those who rag on that the Republican Party is primarily made up of old, rich, racist white men. Be wary because when faced with the prospect of a young Hispanic Republican, as in Marco Rubio, the media seems to think that a question of priority for said Republican is to ask him how old he thinks the Earth is. Let’s disregard how other issues were skipped over in lieu of that high priority age of the Earth question. Issues such as: immigration, the economy, healthcare, gun running into Mexico, a U.S. Ambassador being killed in a coordinated attack at a U.S. Embassy and, maybe, the current conflict between Israel and Hamas, you know - low priority issues like that. Oh, and let’s also disregard the fact that Rubio probably-most-likely-maybe thinks that the laws of aerodynamics work consistently enough so that he believes that when he boards a jetliner it will actually fly through the air (as designed); or that he thinks that the laws of chemistry work consistently enough so that when he takes medication it will interact with his body the way it is supposed to; or that he thinks most of that - you know - “science stuff” really works.

Yes, since they can’t accuse him of being an old, rich, racist white man, they simply disregard all of the real issues and paint him out to be some sort of buffoon by asking him how old the Earth is because, when all is said and done, they’re not interested in tolerating a Hispanic Republican.

Be wary.

Recently there’s been a bit about Ada Lovelace and setting aside a day for noting “important women” in science. Why Ada and not another woman? Some ask, if not Ada, who? I say, not Ada. The only rational choice is Emmy Noether. There was nobody like her. Ever. This started as a comment (at my personal blog) on today’s link thread were this was noted. But it grew into post size, so I’ve promoted it.

The point I’m trying to make if had the name the top 5 most influential people in 20th century physics (ignoring their sex), Emmy Noether would be a top candidate for that list … or possibly even the top 3. The Ada Lovelace thing is for “famous women scientists”. Other names are suggested but … none of which have that stature.  The big question is why don’t people recognize her? Have you heard of Emmy Noether? If not, one might ask is the reason why not due to sexism or anti-semitism (she was a Jew)? Is that a factor? Einstein was a Jew … and it didn’t diminish him .. but it’s a possibility I raise, especially noting in the 30s and 40s anti-Semitism was far more common than it is now.

One other possibility was that it was territorial, i.e., Noether wasn’t a physicist. One might think that it’s embarrassing (for physicists) that one of the biggest theoretical discoveries in your field to be made by some one who just stopped in looked at the maths in your playground for a bit and said, you know “I had this little idea, so I wrote it up.” And subsequently this little paper becomes the cornerstone of your whole science for the next century and counting. In part this is why I find the “Ada Lovelace” kind of thing questionable, there isn’t any question of who the most important women thinker/scientist of the last N years has been, where N is a number larger than 100 (1000? or 10000?). There’s only one candidate, and the other question might be was there anyone male or female who was more influential … perhaps there’s a short short list.  There is not a single other woman who has dominated two separate fields of study and wrenched them both around in such a fundamental way. What men might you make the same claim for, what male scientist revolutionized two separate scientific fields? If you think there is a better candidate, put that name out there .. link or comment .. your choice.

So, was it scientific jealousy? Anti-Semitism? Or sexism? Or something else?

My commenter (this started as a comment response), noted he watches Discover/Cosmos type shows. So, in the nature of a quick “Cosmos” style precis, where does Ms Noether’s work fit in the grand scheme of things? (that explanation goes below the cut) Read the rest of this entry »

No, the Bush tax cuts didn’t cause the recession. Yes, Obama’s "recovery" has been the worst in history. These and other economic realities can be summed up in this graph. (Click for a larger version.)

A sex scandal involving adults and children under their charge. No, not the Catholic church of the 60s; the public schools of today.

While he did get the number wrong, Romney was right in that those who pay the least in income taxes are the least likely to vote for him.

The number of scientific papers that had to be retracted last year was a 10x increase over the rate during the previous decade. And a study of those retractions finds that 3/4ths of those retractions were due to misconduct rather than honest mistakes.

Good news in the stem cell debate. "Two stem-cell researchers have won this year’s Nobel Prize in Physiology or Medicine for their groundbreaking work in cellular reprogramming, a technique that unleashed a wave of advances in biology, from cloning to the possible treatment of diseases using a patient’s own cells." That is, there is less of a reason to use embryonic stem cells, when adult ones will do just as well.

Hedging their bets? "A survey by the Pew Research Center discovered that 2.4 percent of Americans say they are atheists and 3.3 percent say they are agnostic. Among the atheists and agnostics, however, 6 percent said they pray daily."

Need more money for your school district, by proving how many students attend? Make them wear microchips. Privacy takes a back seat to cash.

And finally, some apt scripture for the VP debate last night. (Click for a larger version.)

In  my most recent episode of the "Consider This!" podcast, I discussed how polygamy is beginning to get mainstreamed, with major newspapers asking the question; why is 2 some magic number for marriage? Why not "three, four, or 17"?

The website Gawker is now giving press (and rather disturbing press, frankly; the beginning of the article is not for the squeamish) to guys like Dr. Hubert Van Gijseghem (pronounced HI-sheh-hem), who is retired from the University of Montreal, and who testified before the Canadian Parliament’s "Committee on Justice and Human Rights." In part, he said:

[I]t is a fact that real pedophiles account for only 20 percent of sexual abusers. If we know that pedophiles are not simply people who commit a small offence from time to time but rather are grappling with what is equivalent to a sexual orientation just like another individual may be grappling with heterosexuality or even homosexuality, and if we agree on the fact that true pedophiles have an exclusive preference for children, which is the same as having a sexual orientation, everyone knows that there is no such thing as real therapy. You cannot change this person’s sexual orientation.

And if they’re "born this way" (to steal from a Lady Gaga song title), who are we to judge? I’m not saying that some of the things done to pedophiles is justified (the harassment they receive), because we are to love the thief, the murderer and the pedophile as Christ would love them. I completely denounce harassment, but words mean things, and this is a big step in the cultural normalization process.

At the moment, there is still some sanity on the subject. One group in Germany attempting to counsel pedophiles uses the phrase, "You are not guilty because of your sexual desire, but you are responsible for your sexual behavior. There is help." This is true of all of us. We all have our weak points of temptation, but it’s how we act (and, as Jesus pointed out, how we fantasize) that is the problem.

However, consider how homosexuality was viewed just a generation ago and how it’s been so normalized that some states allow same-sex marriage. The biggest argument that the homosexual crowd put forth was that this was something in their genes, and therefore was nothing more than being left-handed or blue-eyed. If we consider pedophilia just another sexual orientation, then, while the act may still be frowned upon for the moment, the foundation has already been laid to normalize pedophilia.

Now, I know slippery slope arguments can be…well, slippery. They involve a bit of prediction. If A happens, B will happen next. It’s easy to dismiss these sorts of arguments are mere guesses. However, when initial predictions become true, and when you have so much history to look at and see that it has been indeed happening, it’s time to take the arguments more seriously. I am very supportive of efforts to counsel pedophiles before they act on their thoughts. However, the change in terminology can and does change the culture and the views. Whether or not Dr. Van Gijseghem means it to, this change can easily be taken up by others to slip us further down the slope to … well, who knows where.

Remember how Junk-DNA was supposed to be a blatant indication of the process of methodological naturalism? Remember how all that noncoding fluff in the genome was considered the result of the trial and error nature of the evolutionary process?

Yet, it seems that the junk is not so junky after-all.

In the following video by Dr. Fuz Rana, from Reasons to Believe, he tells us of the importance of the Encode DNA Project, and its findings. In the video he states that the Encode DNA team have determined that about 80% of the human genome consist of functional DNA seqences.

I recall a discussion I had years ago with a friend, who accepts the naturalistic evolutionary mindset, and his response to the apparent fact that so much of the genome was noncoding (i.e., “junk”) was, “And that makes sense from an evolutionary point of view.”

What really makes sense, when one sees the vast integrated complexity of the genome, is that one is looking at the work of a designer. A mindless process? Or the process of a mind?

Your neighbor across the aisle does not. Here is some unsolicited advice for the left wing on this topic. If you really think this is a problem, and you want everyone, not just your side of the aisle to push for it futilely … Here’s a newsflash for y’all. You’re selling it wrong.

Look at us over here on the right. We think the space program was cool. We love going to flight museums and wistfully wishing we (as a nation) were still flying SR-71s (RS-71 dammit, stupid Presidents). We gawk at daisy cutters and talk about yields and payloads. While we might take up on those government goodies that are “free” it sticks in our craw and we wish that ‘ol time Yankee rugged individualism wasn’t dying out, killed by bureaucratic mind-numbing cookie cutter schools among other things. Read these two books, here and here. That’s good reading. So, do you like Bob? We do.

In a past era, a Democratic President challenged his nation to go to the moon, not because it was easy but because it was hard. You want a nation to get behind you with a climate crises. Challenge them that way. Tell ‘em to go out and fix it, not by sucking back our economy and going all green-ified on us, scrimping out toilet paper curbing consumption of interesting toys and things to do.

No. Fix it the old fashioned way, with a hammer, tongs, and big bad-ass technology. Challenge us that way, and you might get a rise out of us.

Of course it might alienate you’re side of the aisle, but you can’t break an omelette without making eggs, or something like that.

(with tongue firmly in cheek … and attempting to ignore the silly season somewhat)

The ability to make what are called "induced-pluripotent stem cells" (iPS) has been done before. What’s new now is that making them is becoming easier.

Johns Hopkins scientists have developed a reliable method to turn the clock back on blood cells, restoring them to a primitive stem cell state from which they can then develop into any other type of cell in the body.

The work, described in the Aug. 8 issue of the journal Public Library of Science (PLoS), is "Chapter Two" in an ongoing effort to efficiently and consistently convert adult blood cells into stem cells that are highly qualified for clinical and research use in place of human embryonic stem cells, says Elias Zambidis, M.D., Ph.D., assistant professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.

"Taking a cell from an adult and converting it all the way back to the way it was when that person was a 6-day-old embryo creates a completely new biology toward our understanding of how cells age and what happens when things go wrong, as in cancer development," Zambidis says.

"Chapter One," Zambidis says, was work described last spring in PLoS One in which Zambidis and colleagues recounted the use of this successful method of safely transforming adult blood cells into heart cells. In the latest experiments, he and his colleagues now describe methods for coaxing adult blood cells to become so-called induced-pluripotent stem cells (iPS) — adult cells reprogrammed to an embryonic like state, and with unprecedented efficiencies.

Zambidis says his team has managed to develop a "super efficient, virus-free" way to make iPS cells, overcoming a persistent difficulty for scientists working with these cells in the laboratory. Generally, out of hundreds of blood cells, only one or two might turn into iPS cells. Using Zambidis’ method, 50 to 60 percent of blood cells were engineered into iPS cells.

Click here for other stem cell stories that we’ve covered. The idea that embryonic stem cells are a must-have for research is a myth.

Archeology keeps giving us reasons to believe that the history of Israel we find in the Old Testament is an actual account of real events rather than some epic storytelling of the period. Eric Metaxas, who shares the "Breakpoint Commentaries" duties since the death of Chuck Colson, explains.

The findings at Sorek [of an 11th century BC coin of a man with long hair fighting a large animal, suggesting that Samson-like men actually exited before the account in the Bible] are only the latest in a series of archaeological discoveries that are changing the way modern historians look at biblical narratives. It’s becoming more difficult for them to maintain that the narratives are pious fictions invented long after the era being depicted.

The most famous of these discoveries is the 1994 discovery of a stele in Tel Dan bearing an inscription that contained the words “House of David.” It was the first extra-biblical evidence of the Davidic dynasty. Prior to the discovery, many scholars doubted that David ever existed, much less founded a dynasty. The discovery was so out-of-line with expectations that more than a few insisted it must be a forgery.

Today, it is clear to even the most skeptical scholar that—surprise!—there really was a David who founded a ruling dynasty. That dynasty included his son, Solomon, and evidence of Solomon’s building projects described in Second Samuel have been found by archaeologists as well.

The Bible tells us about God because the events that it represents as historical are, indeed, historical. If they were fictional, they would tell us nothing about the nature of God any more than the story of George Washington chopping down the cherry tree tells us anything about Washington himself. Fictional stories do, indeed, help us explain concepts, but those concepts must pre-exist the story. First we must know what God is like, and we know what He is like by reading about what He did; not some fantasy of what He might have done given a particular situation. Once we know what God is like, fiction and parable are then useful.

So our understanding of God relies on the accuracy of the Bible. And archeology just keeps showing that to be true.

This article at Life News describes recent grants & prize money that went to stem cell research.  There is something to note about how the money way divvied up.

As noted in the earlier Lozier Institute study, the first round of grants under this category, in October, 2009, saw a marked departure by CIRM away from a funding preference for hESCR [human embryonic stem cell research] and towards adult and other non-embryonic stem cell research.

That pattern continues in the July 2012 round of grants. Of eight research projects selected, only one involved hESCs while two involved the use of fetal tissue. The others used ethically non-contentious adult stem cells or other non-embryonic approaches. Of the $150 million awarded, $48 million went to the hESC and fetal tissue projects; the remaining $102 million went to the ethically non-contentious adult stem cell and other non-embryonic projects.

Results are drawing the funding, not political hype, and the trend is away from embryonic stem cells.

No, not Al Gore.

Lovelock is a world-renowned scientist and environmentalist whose Gaia theory — that the Earth operates as a single, living organism — has had a profound impact on the development of global warming theory.

Unlike many “environmentalists,” who have degrees in political science, Lovelock, until his recent retirement at age 92, was a much-honoured working scientist and academic.

His inventions have been used by NASA, among many other scientific organizations.

Lovelock’s invention of the electron capture detector in 1957 first enabled scientists to measure CFCs (chlorofluorocarbons) and other pollutants in the atmosphere, leading, in many ways, to the birth of the modern environmental movement.

But this father of a movement has some scolding for his children. In a previous interview, he noted, “the problem is we don’t know what the climate is doing. We thought we knew 20 years ago.” This was in acknowledgement of the fact that global temperatures just haven’t gone up the way the computer models predicted. Acknowledging that error is certainly a step in the right direction, but let’s not forget that the massive drain on our economy that Greens the world over would have wanted to implement based on those flawed models would have made this recession even worse.

Now, he’s not renouncing man-made global warming, but he is asking folks who do agree with him to just calm down a bit and look at some realities. His advice?

• He’s for more nuclear power and natural gas "fracking".
• Ratchet back the whole green "religion" guilting.
• Modern economies will not be powered by windmills and "so-called ’sustainable development’." That is "meaningless drivel".
• No, the science isn’t settled. That’s not how science works.

Read the whole thing.

Yeah, haven’t posted in a while. I’ve been working on another side project that may or may not pan out. We’ll see. In the meantime, it’s time to play some catch-up on the wrap-up.

No, I don’t believe Obama was born in Kenya, but he certainly let that image get out years ago, and only recently stopped that. As late as 2004, even the Associated Press was referring to "Kenyan-born" Barack Obama. Laugh all you want at the birthers, but they at least had this sort of thing to back them up (for a while).

The Family Research Council has a count of the number of states that have legislated against same-sex marriage. Depending on how you choose what kind of legislation (law, constitutional amendment, etc.), the number changes, but here’s the biggie. "Number of states which currently (May 2012) grant marriage licenses only for unions of one man and one woman:   44" Remember that when you see polls about what people supposedly think about it.

And don’t try to press Martin Luther King into service to that particular cause. He followed his religion in this regard.

“The Iranian nation is standing for its cause that is the full annihilation of Israel.” Their words.

Civility Watch: "Union Leader Takes Bat to Pinata Depicting Gov. Nikki Haley (R-S.C.)"

Michael J. Fox realizes that stem cells, as good as they are, were never some magic cure-all.

Advances in the war:

A record-low 41 percent now identify themselves as “pro-choice,” down from 47 percent last July and 1 percentage point down from the previous record low of 42 percent, set in May 2009. As recently as 2006, 51 percent of Americans described themselves as “pro-choice.”

And speaking of the war, the actual, physical war on women by Planned Parenthood gets exposed by hidden camera videos. Predictably, the media yawns.

Further, "Congressional Black Caucus Upset By Pro-Life Black Americans". Those tolerant folks.

The Washington Post took 20 years to realize that Dan Quayle’s argument against the TV show Murphy Brown was right. It took Candace Bergen 10 years herself. And of course some of us knew that from the beginning.

And finally, oh, that liberal media.

Medical technology is reducing the need for stem cells.

In the laboratory skin cells were treated with a virus, which was modified to ‘infect’ them with agents that function to convert the skin cells into precursors to brain cells. These cells can specialise into the three types of brain cell: neurons, oligodendrocytes and astrocytes. After laboratory research was carried out, the converted cells were injected into the brains of mice. These mice were bred to lack the protein myelin, which is important in aiding the transmission of messages in the brain. 10 weeks later, the precursor cells had specialised into oligodendrocytes, which made the myelin that the mice lacked.

Skin cells directly to brain cells, do not pass Go, do not create ethical issues. (And creating myelin, which is something that someone like me with MS raises their antennae over.)

[Please click here for part 1, as this just picks up where that left off. Also, another blogger found the article again at a new URL on the same site. I'd searched using their advance search form with no success, but glad that it's back so people can read the whole thing.]

The newborn and the fetus are morally equivalent

The authors, Alberto Giubilini and Francesca Minerva,  start this section with their definition of personhood.

Both a fetus and a newborn certainly are human beings and potential persons, but neither is a ‘person’ in the sense of ‘subject of a moral right to life’. We take ‘person’ to mean an individual who is capable of attributing to her own existence some (at least) basic value such that being deprived of this existence represents a loss to her.

Thus, to be a person, you have to know you’re a person and be able to value it. The state of not knowing, however, lasts quite a bit beyond newborn status. The authors, again, fail to address this. More than fail to, actually, they refuse to address it, as we shall see.

Merely being human is not in itself a reason for ascribing someone a right to life. Indeed, many humans are not considered subjects of a right to life: spare embryos where research on embryo stem cells is permitted, fetuses where abortion is permitted, criminals where capital punishment is legal.

The equivalence here is somewhat flawed, not the least because they start to blur the moral right to life with the legal right to life. Further, they equate giving up your legal right to life (by, for example, murdering someone else) with a fetus or embryo being in the wrong place at the wrong time. Depending on your morals, all three examples have a moral right to life, it’s just in the last case it was actively forfeited.

Read the rest of this entry »